2204280-41-9

Name	Benzenemethanamine, 4-[(trifluoromethyl)thio]-N-[[4-[(trifluoromethyl)thio]phenyl]methyl]-
CAS	2204280-41-9
Molecular Formula	C16H13F6NS2
Molecular Weight	397.4
MOL File	2204280-41-9.mol

Synonyms

MY33-3 Benzenemethanamine, 4-[(trifluoromethyl)thio]-N-[[4-[(trifluoromethyl)thio]phenyl]methyl]-

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Chemical Properties

Boiling point	325.0±42.0 °C(Predicted)
density	1.41±0.1 g/cm3(Predicted)
form	Solid
pka	7.26±0.20(Predicted)
color	Off-white to light yellow

Hazard Information

Uses

MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction[1][2][3].

in vivo

MY33-3 (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 reduces preference for the ethanol solution on day 3^[1].
MY33-3 (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability^[3].

Animal Model:	Male C57BL/6J mice (8-10 weeks of age) are received two-bottle drinking in the dark (DID) procedure using 20% ethanol^[1]
Dosage:	60 mg/kg
Administration:	P.o. 1 hour before the drinking session in the DID test on days 3 and 4
Result:	Reduced ethanol consumption when comparing day 2 with day 3. Showed a reduced preference for the ethanol solution. Not affected total fluid consumption.

References

[1] Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. DOI:10.1016/j.neuropharm.2018.04.027
[2] Fernández-Calle R, et, al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10(1):20259. DOI:10.1038/s41598-020-76415-5
[3] Mao S, et, al. Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. J Mol Neurosci. 2022 Jan;72(1):48-55. DOI:10.1007/s12031-021-01885-9

Supplier

Guangzhou Younan Technology Co., Ltd

Telephone020-82000279 18988941452

Websitehttp://www.ubiochem.cn/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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