ChemicalBook CAS DataBase List 2204270-73-3

2204270-73-3

Name	INDEX NAME NOT YET ASSIGNED
CAS	2204270-73-3
Molecular Formula	C15H10F6OS2
Molecular Weight	384.35
MOL File	2204270-73-3.mol

Chemical Properties

Boiling point	309.0±42.0 °C(Predicted)
density	1.45±0.1 g/cm3(Predicted)
storage temp.	-10 to -25°C
solubility	DMSO: 2mg/mL, clear (Warmed)
form	Solid
color	White to off-white

Hazard Information

Uses

MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65 expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases[1][2][3][4][5].

Biological Activity

MY10 is a cell penetrant potent and selective inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. It interacts with the cytoplasmatic D1 domain of RPTPβ/ζ. MY10 reduces alcohol intake in rats.

in vivo

MY10 (100 mg/kg, p.o., 1 h before the voluntary alcohol consumption) reduces the alcohol consumption in rats^[5].

Animal Model:	Adult male Wistar rats (male, 375-440 g) in alcohol operant self- administration paradigm and Drinking In the Dark - Multiple Scheduled Access (DID-MSA) paradigm^[5]
Dosage:	20, 60, 100 mg/kg (in 10% dehydrated ethanol, 20% polysorbate 80, and 70% PEG 300 vehicle)
Administration:	Administered by oral gavage, once 1 hour before the voluntary alcohol consumption, for 3 days.
Result:	Caused a significant 26.1% reduction in alcohol consumption at 100 mg/kg (in the alcohol operant self-administration paradigm). Caused a 28.1% decrease in cumulative alcohol intake (in the DID-MSA paradigm). Decreased the alcohol preference. Had no effect on saccharin intake. Prevented the alcohol-induced down-regulation of Prprzl and Alk gene expression.

References

[1] Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. DOI:10.1016/j.neuropharm.2018.04.027
[2] Del Campo M, et al. Role of Receptor Protein Tyrosine Phosphatase β/ζ in Neuron-Microglia Communication in a Cellular Model of Parkinson's Disease. Int J Mol Sci. 2021 Jun 22;22(13):6646. DOI:10.3390/ijms22136646
[3] Fernández-Calle R, et al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10(1):20259. DOI:10.1038/s41598-020-76415-5
[4] Kastana P, et al. Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth. Int J Cancer. 2023 Sep 1;153(5):1051-1066. DOI:10.1002/ijc.34564
[5] Calleja-Conde J, et al. Inhibition of Receptor Protein Tyrosine Phosphatase β/ζ Reduces Alcohol Intake in Rats. Alcohol Clin Exp Res. 2020 May;44(5):1037-1045. DOI:10.1111/acer.14321

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