219705-77-8

Name	1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid
CAS	219705-77-8
Molecular Formula	C28H28N4O4
Molecular Weight	484.55
MOL File	219705-77-8.mol

Synonyms

ATZ-1993 1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid 1H-Benz[g]indazole-3-carboxylic acid, 1-[1-(3-ethoxyphenyl)propyl]-4,5-dihydro-7-(5-pyrimidinylmethoxy)-

show less show more

Chemical Properties

Boiling point	725.6±60.0 °C(Predicted)
density	1.30±0.1 g/cm3(Predicted)
pka	3.84±0.20(Predicted)

Hazard Information

Uses

ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pKi values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery[1].

in vivo

ATZ-1993 (30 mg/kg; drinking water, daily for 1 week) inhibits the intimal hyperplasia intimal hyperplasia after balloon denudation^[1].

Animal Model:	Japanese White male rabbits^[1]
Dosage:	30 mg/kg
Administration:	Drinking water, daily for 1 weeks
Result:	Inhibited the intimal hyperplasia with the inhibition rate approximately 77%, increased in intima:media ratio and DNA content.

IC 50

ET_A: 8.69 (pKi); ET_B: 7.20 (pKi)

References

[1] Azuma H, et al. ATZ1993, an orally active and novel nonpeptide antagonist for endothelin receptors and inhibition of intimal hyperplasia after balloon denudation of the rabbit carotid artery. Jpn J Pharmacol. 1999 Sep;81(1):21-8. DOI:10.1254/jjp.81.21

Supplier

Chengdu Saiousi Pharmaceutical Co., Ltd

Telephone028-64971018 18108168130

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList20127/0_EN.htm

Career Henan Chemica Co

Telephone+86-0371-86658258 +86-13203830695

Websitehttps://www.coreychem.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Hainan Huaxiang Pharmaceutical Technology Co., Ltd.

Telephone 18389863383

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList360663/0_EN.htm

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy