Synthesis
The reaction of 1 mmol of aniline with 1 mmol of activated α,β-unsaturated compound (Michael receptor, cas:292638-85-8) in appropriate solvent was catalyzed by 5 mol% (0.1 mmol) stabilized cobalt nanoparticles with stirring. The reaction progress was monitored by thin layer chromatography (TLC, unfolding agent: hexane/ethyl acetate). Upon completion of the reaction, dichloromethane was added to the reaction mixture, the cobalt catalyst was separated and recovered using an applied magnetic field, and the remaining reaction mixture was decanted into another flask. Subsequently, the solvent was removed by rotary evaporation to give the crude product. The crude product was further purified by silica gel column chromatography with the eluent being a mixed ethyl acetate/petroleum ether solvent. The structure of the final product was confirmed by 1H NMR, 13C NMR and mass spectrometry.
References
[1] Synthetic Communications, 2009, vol. 39, # 6, p. 1109 - 1119
[2] RSC Advances, 2016, vol. 6, # 98, p. 95951 - 95956
[3] Monatshefte fur Chemie, 2008, vol. 139, # 9, p. 1041 - 1047
[4] Inorganic Chemistry Communications, 2015, vol. 53, p. 92 - 96
[5] Tetrahedron, 2013, vol. 69, # 6, p. 1712 - 1716
