ChemicalBook CAS DataBase List 2183240-70-0

2183240-70-0

Name	DL-THIORPHAN
CAS	76721-89-6
Molecular Formula	C12H15NO3S
MDL Number	MFCD00058435
Molecular Weight	253.32
MOL File	76721-89-6.mol

Synonyms

C01619 THIORPHAN DL-THIORPHAN Thiorphan-d5 THIORPHAN (DL) Bisoprolol FuMarate IMpurity-Q (DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLY DL-3-MERCAPTO-2-BENZYLPROPANOYL-GLYCINE (DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLY-OH ((RS)-2-BENZYL-3-MERCAPTOPROPIONYL)-GLY-OH ((RS)-2-BENZYL-3-MERCAPTOPROPIONYL)-GLYCINE N-[(RS)-2-BENZYL-3-MERCAPTOPROPANOYL]-GLYCINE (+/-)-N-(3-MERCAPTO-2-BENZYLPROPIONYL)GLYCINE 2-(2-benzyl-3-MercaptopropanaMido)acetic acid N-ALPHA-(DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLYCINE rac-N-[(2R*)-3-Mercapto-2-benzylpropionyl]glycine 2-MercaptoMethyl-3-phenylpropionylaMinoacetic Acid N-[2-(MercaptoMethyl)-1-oxo-3-phenylpropyl]glycine 2-[[2-(Benzyl)-3-sulfanylpropanoyl]aMino]acetic acid (DL-3-Mercapto-2-benzylpropionyl)-Gly-OH, (DL-3-Mercapto-2-benzylpropanoyl)-Gly-OH (±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine 2-Mercaptomethyl-3-phenyl-propionylamino-acetic Acid, D,L-3-Mercapto-2-benzylpropanoylglycine,

Chemical Properties

Appearance	Off-White Solid
Melting point	138-140 °C
Boiling point	524.0±50.0 °C(Predicted)
density	1.246±0.06 g/cm3(Predicted)
RTECS	MC0596440
storage temp.	-15°C
solubility	ethanol: 50 mg/mL, clear, colorless
form	White solid
pka	3.48±0.10(Predicted)
color	White to Off-White
BRN	4872101
CAS DataBase Reference	76721-89-6

Safety Data

Safety Statements	22-24/25 less more
WGK Germany	3
F	10
HS Code	29309090

Hazard Information

Chemical Properties

Off-White Solid

Uses

An Enkephalinase inhibitor

Uses

The active metabolite

Uses

Thiorphan is a potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM). It is much less effective against neprilysin-2 (IC50 = 22.1 μM), angiotensin-converting enzyme, and endothelin-converting enzyme-1. Thiorphan can be produced in vivo via the metabolism of the prodrug acetorphan. Neprilysin is overexpressed in many forms of cancer and may play a role in protecting against Alzheimer’s disease.

Definition

ChEBI:Thiorphan is a N-acyl-amino acid.

General Description

A thiol-containing amido-acid that selectively binds to the active site zinc of neprilysin (also known as neutral endopeptidase and NEP) and inhibits its activity (IC₅₀ = 2.1 nM). Inhibits the β-amyloid (Aβ) degrading activity of neprilysin in vivo, but does not affect the secretion of either Aβ peptide or amyloid precursor protein (APP). Also shown to inhibit other neprilysin-related family members, such as mouse NL1 (IC₅₀ = 47 nM) and the neprilysin homolog from Ascaris suum (IC₅₀ = 22 μM). Inhibits the activity of angiotensin-converting enzyme (ACE) (IC₅₀ = 140 nM), but has no effect on the activity of endothelin-converting enzyme (ECE).

Biochem/physiol Actions

Primary TargetNEP activity

Spectrum Detail

Supplier

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

Shanghai Hanhong Scientific Co.,Ltd.

Telephone021-54306202 13764082696

Websitehttps://www.hanhongsci.com

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Daicel Chiral Technologies (China)CO.,LTD

Telephone021-50460086-9 15921403865

Websitehttp://www.daicelchiraltech.cn/reagents/Default.aspx

Syntechem Co.,Ltd

Telephone

Websitehttp://www.syntechem.com/

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Telephone025-66113011 13913916777

Websitehttp://www.aikonchem.com/

Guangzhou Isun Pharmaceutical Co., Ltd

Telephone020-39119399 18927568969

Websitehttp://www.isunpharm.com

Bide Pharmatech Ltd.

Telephone400-164-7117 18317119277

Websitehttp://www.bidepharm.com

Quality Control Solutions Ltd.

Telephone0755-66853366 13670046396

Websitehttp://www.qcsrm.com

Finetech Industry Limited

Telephone027-87465837 19945049750

Websitehttps://www.finetechchem.com/

Mashilabs (Shanghai) Co.,Ltd.

Telephone 19916721580

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16374/0_EN.htm

Hangzhou J&H Chemical Co., Ltd.

Telephone0571-87396432

Websitehttp://www.jhechem.com

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Shanghai GL Peptide Ltd.

Telephone+86-21-61263310 13764994101

Websitehttps://www.chemicalbook.com/supplier/10480342/

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

Shanghai Chaolan Chemical Technology Center

TelephoneQQ：65489617 13301690235

Websitehttp://www.atkchemical.com/

Wuxi Asia Peptide Biotechnology Limited Company

Telephone0510-83583050 13771062561

Websitehttp://www.peptide-search.com

1of4

Related Products

Send Inquriy