2163793-38-0

Mcl-1 Degrader C3 is a novel potent and selective degrader of Mcl-1.

PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM[1].

Mcl-1: 0.78 μM (IC₅₀); Bcl-2: 0.54 μM (IC₅₀)

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[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21. DOI:10.1021/acs.jmedchem.9b00919