2158322-29-1

Name	PROTAC ER Degrader-3
CAS	2158322-29-1
Molecular Formula	C??H??N?O??
MDL Number	MFCD32067948
Molecular Weight	1220.43
MOL File	2158322-29-1.mol

Synonyms

PROTAC ER Degrader-3

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Chemical Properties

Boiling point	1264.4±65.0 °C(Predicted)
density	1.31±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	9.38±0.15(Predicted)

Hazard Information

Description

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC comprises an antibody conjugated via a linker to a PROTAC. PAC extracts from patent WO2017201449A1, compound LP2. PAC is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

Uses

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab)[1].

References

[1]. Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.

Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.

Telephone028-81700200 18116577057

Websitehttps://www.weikeqi-biotech.com/

Jilin Province Woda Biotechnology Co., Ltd.

Telephone 13504435624

Websitehttps://www.wodapro.com

ShenZhen Trendseen Biological Technology Co.,Ltd.

Telephone 13417589054

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList312717/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Adooq Bioscience LLC

Telephone400-025-6535

Websitehttp://www.adooq.cn

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