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CCCI-01 is a centrosome clustering inhibitor. CCCI-01 has selective effects on cancer. CCCI-01 can be used for the research of non-cross-resistant anti-cancer agents with blocking centrosome clustering[1].

CCCI-01 induces the fomation of multipolar spindles in cancer cells containing multipleor supernumerary centromeres. CCCI-01 leads to centromere declusteringdisruption of cell cycle and apoptsis in BT-549 breast cancer cells without affecting bipolar spindles in normal primary human mammary epithelial cells.

[1] Kawamura E, et al. Identification of novel small molecule inhibitors of centrosome clustering in cancer cells. Oncotarget. 2013 Oct;4(10):1763-76. DOI:10.18632/oncotarget.1198