2141981-86-2

TCO-PEG3-acid is a click chemistry PEG linker with a terminal carboxylic acid(CO2H) group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. This reagent can react with tetrazine-containing compounds to form a stable covalent bond. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity.

TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

PEGs

[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001