214045-74-6

General procedure for the synthesis of 4-chlorothiazolo[4,5-C]pyridine using compound (CAS:214045-73-5) as starting material: compound 535a (400 mg, 2.61 mmol) was dissolved in phosphorochloridic acid chloride (5 mL) and heated to reflux for 2 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the reaction was subsequently quenched with saturated sodium bicarbonate solution. The reaction mixture was extracted with ethyl acetate and the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to afford the target product 4-chlorothiazolo[4,5-C]pyridine (180 mg). Mass spectrometry analysis showed [M + H]+ of 171.1.

[1] Tetrahedron Letters, 2010, vol. 51, # 21, p. 2800 - 2802
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