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Estrogen receptor antagonist 5 is a potent antagonist of Estrogen receptor. The estrogen receptor is a ligand-activated transcriptional regulatory protein that mediates induction of a variety of biological effects through its interaction with endogenous estrogens. Estrogen receptor antagonist 5 has the potential for the research of metastatic disease (extracted from patent WO2017174757A1, compound 165)[1].

[1] Sharada Labadie, et al. Tetrahydroisoquinoline estrogen receptor modulators and uses thereof. Patent WO2017174757A1.