2133360-00-4

Name	PROTAC BRD4 Degrader-1
CAS	2133360-00-4
Molecular Formula	C40H37N9O8
MDL Number	MFCD34469876
Molecular Weight	771.78
MOL File	2133360-00-4.mol

Synonyms

PROTAC BRD4 Degrader-1 Acetamide, 2-[2-[4-[[6-(3,5-dimethyl-4-isoxazolyl)-1,4-dihydro-1-methyl-2-oxo-4-phenyl-3(2H)-quinazolinyl]methyl]-1H-1,2,3-triazol-1-yl]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

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Chemical Properties

density	1.52±0.1 g/cm3(Predicted)
form	Solid
pka	10.68±0.40(Predicted)
color	White to off-white

Hazard Information

Uses

PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression[1].

IC 50

BRD4 (BD1): 41.8 nM (IC₅₀)

References

[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228

Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.

Telephone028-81700200 18116577057

Websitehttps://www.weikeqi-biotech.com/

Jilin Province Woda Biotechnology Co., Ltd.

Telephone 13504435624

Websitehttps://www.wodapro.com

ShenZhen Trendseen Biological Technology Co.,Ltd.

Telephone 13417589054

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList312717/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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