2127110-22-7

JAK-IN-25 (compound 19) is a potent JAK inhibitor with IC50s of 6 nM, 21 nM, 8 nM, 1051 nM for TYK2, JAK1, JAK2, JAK3, respectively. JAK-IN-25 inhibits human whole blood IL-12 (HEB IL-12) with an IC50 of 28 nM. JAK-IN-25 has the potential for cancer research[1].

Tyk2: 6 nM (IC₅₀); JAK1: 21 nM (IC₅₀); JAK2: 8 nM (IC₅₀); JAK3: 1051 nM (IC₅₀)

[1] Matthew Frank Brown, et al. Pyrazolo[1,5-a]pyrazin-4-yl derivatives. US20230045252A1.