211566-75-5

LY382884 is a GLU(K5) receptor antagonist. LY382884 selectively binds the GLU(K5) kainate receptor subunit (K(b)=0.6 microM) and has 30 microM or greater affinity for cloned human AMPA receptor subtypes. GluR5-mediated glutamate signaling regulates hypothalamo-pituitary-adrenocortical stress responses at the paraventricular nucleus and median eminence.

LY382884 is a selective antagonist for GluR5 kainate receptor. LY382884 prevents the induction of NMDA receptor independent long-term potentiation (LTP)[1].

ChEBI: LY382884 is a member of benzoic acids.

[1] Bortolotto ZA, et al., Kainate receptors are involved in synaptic plasticity. Nature. 1999 Nov 18;402(6759):297-301. DOI:10.1038/46290