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N-(Azido-PEG2)-N-Biotin-PEG3-acid is aclick chemistry biotinylation reagent. The azide group enables Click Chemistry. The terminal carboxylic acid can react with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

N-(Azido-PEG2)-N-biotin-PEG3-acid is a PEG derivative which contains biotin and carboxylic acid moieties. N-(Azido-PEG2)-N-biotin-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups[1].

[1] Robert C. James, et al. Conjugation reagents and methods using 1,2-cyclohexanediones. WO2022094148A1.