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Azido-PEG3-succinimidyl carbonate is a PEG linker that contains azide and succinimdyl carbonate moieties. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes. The succinimidyl carbonate group is a good leaving group and commonly reacts with amine nucleophiles. The hydrophilic PEG linker increases the water solubility of the compound.

Azido-PEG3-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-O-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005