NOP agonist-1(compound 4) is a nociceptin opioid receptor (NOP) partial agonist. NOP agonist-1attenuate parkinsonian disabilities in 6-OHDA hemilesioned rats[1].
References
[1] Kamakolanu UG, et al. Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem. 2020;63(5):2688-2704 DOI:10.1021/acs.jmedchem.9b02134
