2098799-78-9

(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs[1]. (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

VH 032, propargyl is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC? research and development; incorporates an E3 ligase ligand with terminal propargyl ready for conjugation to a target protein ligand.

VHL

Store at -20°C

[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781