2098488-36-7

UUN 88367, also known as Azido-Thalidomide is a clickable Thalidomide derivative, used as a building block for cereblon. Azido-Thalidomide targets PROTACs by hijacking cereblon as the E3 ubiquitin ligase component. This product has no formal name at the moment.

Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cereblon

Store at -20°C

[1] Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491. DOI:10.1021/acs.jmedchem.6b01872