ChemicalBook CAS DataBase List 209414-07-3

209414-07-3

Name	1-Pentyl-3-(1-naphthoyl)indole
CAS	209414-07-3
EINECS(EC#)	200-659-6
Molecular Formula	C24H23NO
MDL Number	MFCD11846245
Molecular Weight	341.45
MOL File	209414-07-3.mol

Chemical Properties

Appearance	White Powder
Melting point	55-59°C
Boiling point	534.2±23.0 °C(Predicted)
density	1.09±0.1 g/cm3(Predicted)
Fp	9℃
storage temp.	Desiccate at -20°C
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Methanol: 30 mg/ml
form	A neat solid
color	white to beige
InChI	1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3
InChIKey	JDNLPKCAXICMBW-UHFFFAOYSA-N
SMILES	O=C(C1=CN(CCCCC)C2=C1C=CC=C2)C3=CC=CC4=C3C=CC=C4

Safety Data

Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25-25 less more
Safety Statements	7-16-36/37-45 less more
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
Storage Class	11 - Combustible Solids
Hazard Classifications	STOT SE 3
Hazardous Substances Data	209414-07-3(Hazardous Substances Data)
DEA Controlled Substances	CSCN: 7118 CSA SCH: Schedule I NARC: No

Hazard Information

Chemical Properties

White Powder

Uses

Analgesic Drug

Uses

JWH 018 is the 18th compound synthesized in a series of more than 470 analogs and metabolites of ?9-Tetrahydro- cannabinol (THC) (T293200), the active component of marijuana. JWH 018 acts as cannabinoid receptor. Controlled substance.

Biological Activity

Potent cannabinoid receptor agonist with mild selectivity for CB 2 (K i values are 2.94 and 9.0 nM for CB 2 and CB 1 receptors respectively).

Description

JWH 018 (CRM) (Item No. 27973) is a certified reference material categorized as a synthetic cannabinoid. It has been found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 018 is regulated as a Schedule I compound in the United States. JWH 018 (CRM) (Item No. 27973) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Definition

ChEBI: JWH 018 is an indolecarboxamide.

References

[1] MARIE H DEVENTER. Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo-Pyridyl Synthetic Cannabinoid Receptor Agonist CH-FUBBMPDORA.[J]. Drug Testing and Analysis, 2025. DOI: 10.1002/dta.3854
[2] KATHARINA ELISABETH GRAFINGER. Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays. Part III: The G protein pathway and critical comparison of different assays[J]. Drug Testing and Analysis, 2021, 13 7: 1412-1429. DOI: 10.1002/dta.3054
[3] ANNELIES CANNAERT. Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA[J]. ACS Chemical Neuroscience, 2020, 11 24: 4434-4446. DOI: 10.1021/acschemneuro.0c00644

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