2093400-18-9

Name	OTS186935
CAS	2093400-18-9
Molecular Formula	C25H26ClN5O2
MDL Number	MFCD32067936
Molecular Weight	463.96
MOL File	2093400-18-9.mol

Synonyms

OTS186935 OTS-186935;OTS 186935

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Chemical Properties

density	1.33±0.1 g/cm3(Predicted)
form	Solid
pka	7.32±0.50(Predicted)
color	Off-white to light yellow

Hazard Information

Description

OTS186935 is a protein methyltransferase SUV39H2 inhibitor. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. It regulates the production of γ-H2AX in cancer cells.

Uses

OTS186935 is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 regulates the production of γ-H2AX in cancer cells[1].

in vivo

OTS186935 (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models^[1].

Animal Model:	Female NOD.CB17-Prkdcscid/J mice (bearing MDA-MB-231 cells )^[1]
Dosage:	10 mg/kg
Administration:	Intravenously; once daily for 14 days
Result:	Tumor growth inhibition of 42.6% on day 14.

Animal Model:	Female BALB/cAJcl-nu/nu mice (bearing A549 cells)^[1]
Dosage:	25 mg/kg
Administration:	Intravenously; once daily for 14 days
Result:	Yielded a tumor growth inhibition of 60.8% without significant body weight loss or toxicity.

References

[1] Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831. DOI:10.18632/oncotarget.25806

Supplier

Fan De(Beijing) Biotechnology Co., Ltd.

Telephone 15911056312

Websitehttp://www.bio-fount.com/

DC Chemicals

Telephone021-58447131 13564518121

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList927327/0_EN.htm

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

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