2088281-24-5

Name	CAQK peptide
CAS	2088281-24-5
Molecular Formula	C17H32N6O6S
Molecular Weight	448.54
MOL File	2088281-24-5.mol

Synonyms

CAQK peptide Cys-Ala-Glu-Lys L-Lysine, L-cysteinyl-L-alanyl-L-glutaminyl-

show less show more

Chemical Properties

Boiling point	913.554±65.00 °C(Press: 760.00 Torr)(predicted)
density	1.299±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
form	Solid
pka	3.271±0.10(predicted)
color	White to off-white
Sequence	Cys-Ala-Glu-Lys

Hazard Information

Uses

CAQK peptide selectively binds to injured mouse brain. CAQK peptide selectively targets demyelinating areas and it is absent from healthy tissue. The CAQK peptide target is a proteoglycan complex upregulated in brain injuries and is used for drug delivery. CAQK peptide can penetrate the blood-brain barrier[1][2].

in vivo

CAQK (100 nmoles/100 μL into the tail vein; at 24 h or 5 days post-injury) homes to lysolecithin-induced focal lesions in the spinal cord.

Animal Model:	C57BL/6J 8-week-old male mice^[1]
Dosage:	100 nmoles/100 μl in PBS
Administration:	Tail vein; at 24 h or 5 days post-injury (focal demyelination was induced by stereotaxic injection of 1 μL of 1% lysolecithin solution into the right ventral)
Result:	Caused the accumulation of peptide at the injury site by an increased density of mononucleated DAPI⁺ cells and fragmented myelin stained for myelin basic protein. The peptide was not detected in the spinal cords of control sham-operated (PBS injected) mice showing regular densities of DAPI⁺ cells.

References

[1] Charly Abi-Ghanem, et al. CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries. Front Cell Neurosci. 2022 Aug 22:16:908401. DOI:10.3389/fncel.2022.908401
[2] Aman P Mann, et al. A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries. Nat Commun. 2016 Jun 28:7:11980. DOI:10.1038/ncomms11980

Supplier

Hangzhou Peptidego Biotech Co.,Ltd.

Telephone0571-87213919

Websitehttp://peptidego.com

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Telephone0571-87213919 17306812703

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1355681/0_EN.htm

Shanghai HongTide Biotechnology Co.,Ltd.

Telephone15318089928

Websitehttps://www.hongtide.com/index.php

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Telephone+86-13017695106 +86-13676922317

Website

Changsha MOL Changes Biotechnology Co., Ltd.

Telephone +8619375158599

Websitehttps://www.molchanges.com

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy