20744-39-2

823-58-5

20744-39-2

General procedure for the synthesis of 4-aminopyridazine from 3,6-dichloropyridazin-4-amine: 1. 3,6-dichloropyridazin-4-amine (5.00 g, 18.2 mmol) was dissolved in tetrahydrofuran (100 ml), sodium hydroxide (8.00 g, 200 mmol) and water (32 ml) were added. 2. 10% palladium-carbon catalyst (500 mg) was added to the above mixture and the reaction was stirred for 2 days at room temperature under hydrogen atmosphere. 3. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated. 4. 4. The concentrated residue was dissolved in methanol (100 ml), filtered again to remove the insoluble material, and the filtrate was concentrated to obtain the target product 4-aminopyridazine as a solid. Product characterization: 1H-NMR (DMSO-d6) δ; 2.51 (2H, br s), 6.00 (1H, br s), 7.81-7.85 (1H, m), 7.98-8.00 (1H, m).