20568-22-3

Preparative Methods of 4-Dimethylamino-3-butyn-2-one: bromination of 4-(dimethylamino)but-3-en-2-one leads essentially in quantitative yield to the hydrobromide which is treated with Triethylamine. Further treatment with Potassium t-Butoxide leads to the title reagent.^[1-2]

4-Dimethylamino-3-butyn-2-one is thermally unstable and is best stored at below -50 °C if kept for a prolonged period.

1. Hafner, K.; Neuenschwander, M. AG(E) 1968, 7, 459.
2. Gais, H.; Hafner, K.; Neuenschwander, M. HCA 1969, 52, 2641.