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Orexin B rat, mouse has been used to test its effect on social interaction in the stress-resilient mice.

Orexin is a neuropeptide that modulates the energy and metabolism balance. The effects of orexin are mediated by one of the two G protein-coupled receptors, orexin receptor 1 or 2. OXRs are expressed in oxinergic projection areas of the brain and regulate food intake by reducing systemic and brain signals that drive over-eating. Synthetic peptide corresponding to the C-terminus of human orexin receptor 1, conjugated to KLH. The immunizing peptide has 70% homology with the rat and mouse gene.

Orexin A, also known as hypocretin 1 (hcrt1), is a 33 amino acid excitatory neuropeptide, localized in a small set of neurons in the perifornical area of the hypothalamus. It is synthesized from the precursor protein prepro-orexin in neurons. Orexin A binds to its G-protein-coupled receptor orexin-1 (OX1), which is also called as hcrt receptors 1 (hcrtr1).

Orexins (hypocretins) comprise a family of hypothalamic peptides that are involved in the initiation of sleep and in feeding behavior. Orexin A stimulates food intake through activation of the OX1 receptor. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons.