2055757-40-7

Name	SHP394
CAS	2055757-40-7
Molecular Formula	C20H25F3N6O2S
MDL Number	MFCD31813754
Molecular Weight	470.51
MOL File	2055757-40-7.mol

Synonyms

SHP394

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Chemical Properties

Boiling point	542.8±60.0 °C(Predicted)
density	1.56±0.1 g/cm3(Predicted)
form	Solid
pka	9.43±0.40(Predicted)
color	White to off-white

Hazard Information

Description

SHP289-04 is a novel glucokinase activator (gka), accelerating glucose consuming in hepatocytes, promoting glucose-stimulated insulin secretion in nit cell line. normalizing oral glucose tolerance test and down-regulated blood lipid level in kkay mice

Uses

SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM[1].

in vivo

SHP394 (20-80 mg/kg; oral gavage; twice daily) dose-dependent reduces tumor volume^[1].
SHP394 (80 mg/kg; oral gavage; twice daily) causes tumor 34% regression and reduces mouse host bodyweight after dosing for 14 days^[1].

Animal Model:	Six-week old female athymic NU/NU mice were inoculated subcutaneously with Detroit-562 pharyngeal carcinoma cells^[1].
Dosage:	20, 40, and 80 mg/kg
Administration:	Oral gavage; twice daily
Result:	Demonstrated a clear dose-dependent reduction in tumor volume.

References

[1] Sarver P, et al. 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. J Med Chem. 2019 Feb 28;62(4):1793-1802. DOI:10.1021/acs.jmedchem.8b01726

Supplier

ShangHai Caerulum Pharma Discovery Co., Ltd.

Telephone18149758185 18149758185;

Websitehttp://www.caerulumpharma.com

TargetMol Chemicals Inc.

Telephone 4008200310

Websitehttps://www.targetmol.cn/

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

Biosynth Biological Technology (Suzhou) Co Ltd

Telephone 51288865780

Websitehttp://www.biosynth.com

Adooq Bioscience LLC

Telephone400-025-6535

Websitehttp://www.adooq.cn

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