2055078-49-2

MNK8 is a novel inhibitor of STAT3 activation, reducing DNA binding ability, increasing SubG1 cell population and inducing apoptosis in HCC cells.

MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells[1].

STAT3; Bcl-2

[1] Sajith AM, et al. Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 2021 Oct 15;50:128332. DOI:10.1016/j.bmcl.2021.128332