203061-35-2

SCH 60057 is a fungal metabolite that has been found in Acremonium and a neurokinin receptor (NK) antagonist (IC₅₀s = 6 and 12 μM for NK₁ and NK₂, respectively).

SCH 60057 (Compound 7) is a neurokinin (NK) receptor inhibitor that can be isolated from Acremonium sp., with IC50 values of 6 μM and 12 μM for NK1 and NK2, respectively[1].

[1] Hegde VR, et al. Neurokinin receptor inhibitors: fermentation, isolation, physico-chemical properties, structure and biological activity. J Antibiot (Tokyo). 1997 Dec;50(12):983-91. DOI:10.7164/antibiotics.50.983