20271-20-9

67-56-1

1072-84-0

20271-20-9

The general procedure for the synthesis of methyl 5-nitro-1H-imidazole-4-carboxylate from methanol and 1H-imidazole-4-carboxylic acid was as follows: 45.0 g (0.56 mol) of ammonium nitrate was added in small amounts in batches to 160 ml of concentrated sulfuric acid solution containing 20.0 g (0.18 mol) of 1H-imidazole-4-carboxylic acid at 100 °C. The reaction mixture was stirred continuously at this temperature for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by the slow addition of 60 ml of methanol and maintaining stirring. Next, the reaction solution was warmed to 60°C and stirring was continued for 24 hours. At the end of the reaction, the mixture was cooled and poured into ice water to obtain a fine white solid precipitate.