Description
m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types.1?Inhibits growth of U937 and THP-1 cells.2 m-3M3FBS also affects calcium homeostasis independently of PLC activation.3
Uses
m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis1. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells2.
Uses
m-3M3FBS is used in biological studies as phospholipase C activator m-3M3FBS effects on Ca2+ homeostasis independently of phospholipase C activation.
Definition
ChEBI: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide.
Biological Activity
Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca 2+ release and inositol phosphate formation in a variety of cell types.
Biochem/physiol Actions
First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).
References
1) Bae?et al. (2003),?Identification of a compound that directly stimulates phospholipase C activity; Mol. Pharmacol.,?63?1043
2) Lee?et al. (2005),?The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis; Cancer Lett.,?222?227
3) Krjukova?et al. (2004),?Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation; Br. J. Pharmacol.,?143?3
