VU6001966 (compound 15m) is a potent and cross the blood-brain barrier mGlu2 (metabotropic glutamate receptor 2) negative allosteric modulator with IC50s of 78 nM and >30 μM for mGlu2 and mGlu3, respectively. VU6001966 can serve as an mGlu2 PET tracer[1].
IC 50
mGluR2: 78 nM (IC50); mGluR3: >30 μM (IC50)
storage
Store at -20°C
References
[1] Bollinger KA,et al. Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core. ACS Med Chem Lett. 2017 Aug 3;8(9):919-924. DOI:10.1021/acsmedchemlett.7b00279
