199328-35-3

General procedure for the synthesis of ethyl 4-bromo-2-nitrophenylacetate from ethanol and 2-(4-bromo-2-nitrophenyl)acetic acid: to a solution of 2-(4-bromo-2-nitrophenyl)acetic acid (7.00 g, 27.0 mmol) in ethanol (60 mL) was slowly added concentrated sulfuric acid (1 mL). The reaction mixture was heated to reflux and maintained for 2 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure. The concentrated residue was dissolved in ethyl acetate (250 mL) and separated by extraction with saturated sodium carbonate solution (50 mL). The organic layer was washed sequentially with saturated sodium carbonate solution (50 mL) and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give ethyl 4-bromo-2-nitrophenylacetate (8.00 g, 98% yield) as an ester liquid.

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