197777-71-2

FMS is a fluorescent reagent with high selectivity.

FMS also called CSF1R colony stimulating factor 1 receptorand its ligand CSF1 are linked to poor prognosis in patients with solid tumorsand in patients with female reproductive cancers. In breast cancers with decreased claudin levelsthis protein regulates the switch between proliferative and invasive state of the tumoracting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial functionwhich might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).