SB 221284 is a potent, selective SR-2C/SR-2B antagonist.
Definition
ChEBI: SB 221284 is an indolyl carboxylic acid.
Biological Activity
Potent, selective 5-HT 2C/2B receptor antagonist. pK i values are 6.4, 7.9 and 8.6 for 5-HT 2A , 2B and 2C receptors respectively. Centrally active upon systemic administration in vivo .
in vivo
SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1]
Animal Model:
Male Sprague Dawley rats (250–360 g)[1]
Dosage:
0.1~1 mg/kg
Administration:
I.p.
Result:
Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
Animal Model:
Male Sprague Dawley rats (250–360 g)[1]
Dosage:
1 mg/kg
Administration:
I.p.
Result:
Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.
