19553-26-5

(±)-Isocyclopenine is the racemic form of metabolites of natural product cyclopeptine (C991620) isolated from Penicillium cyclopium. Intermediate in the biosynthesis of the viridicatins.

Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicillium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of 3-O-methyl viridicatin, a strong inhibitor of TNFα-induced replication HIV. Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite.

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