193825-78-4

Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs).¹ Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC₅₀ value of 11.8 μM.¹

Commendamide is a GPCR G2A/GPR132 agonist (EC50: 11.8 μM). Commendamide can be used for research of autoimmunity and atherosclerosis[1].

ChEBI: N-(3-Hydroxy-1-oxohexadecyl)-glycine is a N-acyl-amino acid.

1. Cohen, L.J., Kang, H.S., Chu, J., et al. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist Proc. Natl. Acad. Sci. USA 112(35),E4825-E4834(2015).