JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3[1].
References
[1] Sikkema BJ, et al. Quantification and clinical validation of the selective MET kinase inhibitor DO-2 and its metabolites DO-5 and M3 in human plasma. J Pharm Biomed Anal. 2024 Jan 4;240:115962. DOI:10.1016/j.jpba.2024.115962
