193356-17-1

Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50values are 0.043, > 100 and > 100μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effectsin vivoandin vitro.

Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].

Store at +4°C

[1] Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9. DOI:10.1073/pnas.0903546106