193354-70-0

S1R agonist 1 (Compound 6b) is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].

Sigma 1 Receptor: 0.93 nM (Ki); Sigma 2 Receptor: 72 nM (Ki)

[1] Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163. DOI:10.1016/j.ejmech.2023.115163