Profluazol is commercially produced by a process that begins with the preparation of a (6S,7aR)-6-fluoro-1,3-dioxo-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazole intermediate, which is then reacted with a 2-chloro-4-fluoro-5-aminophenylmethanesulfonyl chloride under amide or sulfonamide coupling conditions. This reaction typically employs organic solvents and base catalysts to ensure regioselectivity and yield.
Mechanism of action
Inhibition of protoporphyrinogen oxidase (PPO) - cell membrane disruption
