ChemicalBook CAS DataBase List 189308-08-5

189308-08-5

Name	danshenol A
CAS	189308-08-5
Molecular Formula	C21H20O4
MDL Number	MFCD31618831
Molecular Weight	336.38
MOL File	189308-08-5.mol

Chemical Properties

Boiling point	571.5±50.0 °C(Predicted)
density	1.31±0.1 g/cm3(Predicted)
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	powder
pka	10.86±0.40(Predicted)
color	Red

Hazard Information

Uses

Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research[1][2][3][4].

Cytotoxicity

IC₅₀ (μg/mL): 1.93 (HeLa), 2.22 (KB-3-1),3.97 (NCI-H460), 1.07 (PC3), 3.21(MCF-7), 0.63 (K562) (Wu et al. 2014)

in vivo

Danshenol A (0.3-3?mg/kg; p.o; daily; for 12 weeks) ameliorates blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function in SHR rats. Danshenol A repaires the structure/function of the mitochondria, alleviated oxidative stress in the myocardium^[2].

Animal Model:	Forty male spontaneously hypertensive rats (SHR) and eight male Wistar-Kyoto (WKY) rats at the age of 16 weeks^[2]
Dosage:	0.3?mg/kg, 1?mg/kg, 3?mg/kg
Administration:	Orally administration; daily; for 12 weeks
Result:	Ameliorated blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function.

References

[1] Wenwen Zhao, et al. Danshenol A inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) mediated by NOX4 in endothelial cells. Sci Rep. 2017 Oct 11;7(1):12953. DOI:10.1038/s41598-017-13072-1
[2] Kai Chen, et al. Danshenol A Alleviates Hypertension-Induced Cardiac Remodeling by Ameliorating Mitochondrial Dysfunction and Suppressing Reactive Oxygen Species Production. Oxid Med Cell Longev. 2019 Sep 11;2019:2580409. DOI:10.1155/2019/2580409
[3] Y Tezuka, et al. Aldose reductase inhibitory constituents of the root of Salvia miltiorhiza Bunge. Chem Pharm Bull (Tokyo). 1997 Aug;45(8):1306-11. DOI:10.1248/cpb.45.1306
[4] Gang Xu, et al. Two new abietane diterpenoids from Salvia yunnanensis. Planta Med. 2006 Jan;72(1):84-6. DOI:10.1055/s-2005-873184

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