189275-71-6

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].

Caspase-1: 56 pM (Ki)

[1] Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. DOI:10.1016/j.chembiol.2010.07.011
[2] Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55. DOI:10.1016/s1074-5521(97)90258-1