18927-72-5

This alkaloid has been isolated from the roots of Thalictrum dasycarpum Fisch. et al. It crystallizes as colourless rods from Et20 or needles from EtOH. It has a specific rotation of[α]²⁵_D - 210° (c 0.21, CHCI3) and gives an ultraviolet spectrum in EtOH with a single absorption maximum at 289 nm. The methyl ether forms needles from Et20-EtOH with m.p. 91-2°C. The structure has been proved by total synthesis of the base.

Kupchan, Yoshitaka,J. Org. Chem., 34,1062 (1969)