ChemicalBook CAS DataBase List 18838-38-5

18838-38-5

Name	N-(phosphonoamidino)sarcosine, dipotassium salt
CAS	18838-38-5
EINECS(EC#)	242-619-0
Molecular Formula	C4H8K2N3O5P
MDL Number	MFCD00065457
Molecular Weight	287.294
MOL File	18838-38-5.mol

Chemical Properties

storage temp.	Store at -20°C
solubility	5 mg/ml in PBS (pH 7.2)
form	solid
color	white
Water Solubility	water: 5mg/mL
EPA Substance Registry System	Glycine, N-[imino(phosphonoamino)methyl]-N-methyl-, dipotassium salt (18838-38-5)

Safety Data

TSCA	TSCA listed

Hazard Information

Uses

Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway.[1][2][3][4].

in vivo

Phosphocreatine (200 mg/kg, i.p., once every other day, 7 weeks) not only alleviates oxidative stress and myocardial apoptosis, but also rescues myocardial necroptosis in DOX-induced cardiotoxicity of rat^[2].
Phosphocreatine (20-40 mg/kg, i.v., daily, 6 weeks) has a protective effect on the kidney tissues against diabetic nephropathy in SD (Sprague Dawley) rats^[4].

Animal Model:	Male Sprague Dawley (SD) rats were divided into three groups, normal control group, DOX group and phosphocreatine group^[2].
Dosage:	200 mg/kg
Administration:	i.p., once every other day, 7 weeks
Result:	Improved the heart function abnormality. Lowered myocardial apoptosis. Recovered the expression of Nrf2, SOD, FoxO3a and diminished C-Casp3, Bax/Bcl2 in the myocardial tissue of rats. Markedly improved myocardial necroptosis, as indicated by decreasing expression of RIP3 and CaMKII. Increased expression level of TAK1.

Animal Model:	Male Sprague Dawley (SD) rats were divided into five groups: control group, model group (STZ(Streptozotocin) (HY-13753)), low dose group (STZ+ phosphocreatine 22 mg/kg) and high dose group (STZ (HY-13753) + phosphocreatine 40 mg/kg). ^[4].
Dosage:	20, 40 mg/kg
Administration:	i.v., daily, 6 weeks
Result:	Reduced hyperglycemia compared with STZ (Streptozotocin) (HY-13753) -treated rats. Increased the weight of rats gradually compared with STZ (Streptozotocin) (HY-13753) group. Decreased kidney weight index (kidney weight/body weight). Decreased MDA level and increased of GSH and SOD levels compared with STZ group. Decreased the apoptotic rate compared with MGO-treated groups.

IC 50

Human Endogenous Metabolite

References

[1] Feldman EB, et al. Creatine: a dietary supplement and ergogenic aid. Nutr Rev. 1999 Feb;57(2):45-50. DOI:10.1111/j.1753-4887.1999.tb01777.x
[2] Wang C, et al. Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro. Toxicology. 2021 Aug;460:152881. DOI:10.1016/j.tox.2021.152881
[3] Li H, et al. Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways. Free Radic Biol Med. 2018 May 20;120:228-238. DOI:10.1016/j.freeradbiomed.2018.03.014
[4] Shopit A, et al. Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway. Life Sci. 2020 Feb 1;242:117248. DOI:10.1016/j.lfs.2019.117248

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