ChemicalBook CAS DataBase List 188125-42-0

188125-42-0

Name	(±)-18-Methoxycoronaridine
CAS	188125-42-0
Molecular Formula	C22H28N2O3
Molecular Weight	368.48
MOL File	188125-42-0.mol

Chemical Properties

Boiling point	510.1±50.0 °C(Predicted)
density	1.25±0.1 g/cm3(Predicted)
form	Solid
pka	16.59±0.60(Predicted)
color	White to off-white

Hazard Information

Uses

Zolunicant (MM-110) is a potent inhibitor against nicotinic α3β4 receptors with an IC50 of 0.90 μM to combat addiction. Zolunicant can decrease the self-administration of several addictive agents including morphine, methamphetamine, nicotine, and ethanol in rat model. Zolunicant can be studied as a potential research for multiple forms of agent abuse[1]. Zolunicant also reveals a potent leishmanicide effect against Leishmania amazonensis[2].

in vivo

Zolunicant (18-MC; Intravenous administration; 0-20 μg a day;14 days) decreases morphine self-administration by blocking α3β4 nicotinic receptors in the habenulo-interpeduncular pathway^[3].

Animal Model:	Na?ve female Long-Evans derived rats^[3]
Dosage:	0,10 and 20 μg
Administration:	Intravenous administration; once a day; 14 days
Result:	Infused into the medial habenula and interpeduncular nucleus decreased morphine self-administration (interpeduncular nucleus: F(5,29) = 6.89, P < 0.0001; medial habenula: F(4,28) = 3.07, P < 0.03).

IC 50

Leishmania

References

[1] Pace CJ, et al. Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration. European journal of pharmacology. 2004;492(2-3):159-67. DOI:10.1016/j.ejphar.2004.03.062
[2] Delorenzi JC, et al. In vitro activities of iboga alkaloid congeners coronaridine and 18-methoxycoronaridine against Leishmania amazonensis. Antimicrob Agents Chemother. 2002;46(7):2111-5. DOI:10.1128/AAC.46.7.2111-2115.2002
[3] Glick SD, et al. 18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats. European journal of pharmacology. 2006;537(1-3):94-8. DOI:10.1016/j.ejphar.2006.03.045

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