Synthesis
GENERAL PROCEDURE: Iron(III) trifluoromethanesulfonate (Fe(OTf)3, 1 mol%) was added to a mixture containing o-aminophenol (1 mmol) and di-tert-butyl dicarbonate (Boc2O, 1 mmol) at room temperature with simultaneous magnetic stirring. The reaction mixture was continuously stirred until the reaction was complete (monitored by thin layer chromatography, TLC). After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and washed with water. The organic layer was separated and dried with anhydrous magnesium sulfate (MgSO4). Finally, the solvent was removed by distillation under vacuum to obtain high purity N-Boc-2-aminophenol.
References
[1] Tetrahedron Letters, 2006, vol. 47, # 7, p. 1087 - 1091
[2] Journal of Chemical Research, 2013, vol. 37, # 12, p. 757 - 760
[3] Asian Journal of Chemistry, 2017, vol. 29, # 6, p. 1313 - 1316
[4] Journal of Organic Chemistry, 2002, vol. 67, # 14, p. 4882 - 4892
[5] Comptes Rendus Chimie, 2010, vol. 13, # 5, p. 544 - 547
