186303-55-9

DU-14 (186303-55-9) inhibits steroid sulfatase (IC50=ca. 60 nM). Enhances learning and spatial memory in rats.1 Inhibits proliferation of human MCF-7 breast cancer cells.2

DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity[1][2][3].

1) Johnson et al. (2000), The effect of steroid sulfatase inhibition on learning and spatial memory; Brain Res., 865 286 2) Selcer et al. (1997), Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines; Cancer Res., 57 702