185517-74-2

(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible MAO inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively[1]. (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

TVP1022the S-isomer of rasagilinean anti-Parkinson drugappears to have the same neuroprotective activity as the R-isomerbut is 1000-fold less active as an MAO-B inhibitor. TVP1022 a neuroprotective and cytoprotective moleculeis also cardioprotective in r at models. Its activity is believed to involve stabilization of mitochondrial membrane potentialinduction of Bcl-2 and activation of the PKC signalling pathwayenhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β.

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[1] M B Youdim, et al. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001 Jan;132(2):500-6. DOI:10.1038/sj.bjp.0703826