185453-02-5

O-Desmethyl-cis-tramadol (hydrochloride) (CRM) (Item No. 18751) is a certified reference material that is structurally categorized as an opioid. It is the main metabolite of cis-tramadol (Item Nos. ISO60149 | 15919). O-Desmethyl-cis-tramadol has ~400-500-fold higher affinity for μ-opioid receptors than the parent compound. However, O-desmethyl-cis-tramadol poorly suppresses the human serotonin transporter, unlike cis-tramadol. This product is intended for research and forensic applications.

White Solid

A metabolite of Tramadol, an analgesic.

[1] MADELEINE RAMONA VOLZ  Bjoern M. Development of a non-radioactive mass spectrometry-based binding assay at the μ-opioid receptor and its application for the determination of the binding affinities of 17 opiates/opioids as well as of the designer opioid isotonitazene and five further 2-benzylbenzimidazoles[J]. Analytica Chimica Acta, 2022, 1219: Article 339978. DOI: 10.1016/j.aca.2022.339978
[2] ATSUSHI NAKAMURA. Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice.[J]. Psychopharmacology, 2008, 200 3: 307-316. DOI: 10.1007/s00213-008-1180-1
[3] W. WU. Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog[J]. Xenobiotica, 2001, 31 1: 423-441. DOI: 10.1080/00498250110057378