ChemicalBook CAS DataBase List 185351-23-9

185351-23-9

Name	L-Tryptophan, N-(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)-
CAS	185351-23-9
Molecular Formula	C21H15ClN2O4
Molecular Weight	394.81
MOL File	185351-23-9.mol

Chemical Properties

Boiling point	638.7±55.0 °C(Predicted)
density	1.52±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	3.89±0.10(Predicted)
color	Brown to reddish brown

Hazard Information

Description

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein[1][2].

Cl-NQTrp efciently disassembled pre-formed PHF6 peptide fbrils[1].Cl-NQTrp has the potential to induce conformational changes in PHF6 peptide oligomers[1].

Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau[2].Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29[2].

Uses

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein[1][2].

in vivo

Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau^[2].
Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29^[2].

Animal Model:	Virgin females, carrying either the eye GMR -Gal4 driver or the pan-neuronal driver elav^c155 -Gal4 on chromosome X, were collected and crossed with males carrying UAS-h tau on the 2nd chromosome or with wild-type Oregon-R (OR) males as a control^[2].
Dosage:	0.75 mg/mL.
Administration:	Dripped every other day.
Result:	Inhibited PHF6 aggregation and ameliorates eye neurodegeneration Drosophila overexpressing the human tau protein (htau).

storage

Store at -20°C

References

[1]. V Guru KrishnaKumar, et al. Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids. Sci Rep. 2018 Jan 8;8(1):71.
[2]. Moran Frenkel-Pinter, et al. Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity. Neurodegener Dis. 2017;17(2-3):73-82.

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